HCID 89546799, compound → HCID 89546797, compound

HRID 2171269Notes

Reaction equation

HRID 2171269 reaction equation
C([N:8](O)[C@H:9]([CH3:21])[C@@H:10]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:11][CH3:12])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO>[NH2:8][C@H:9]([CH3:21])[C@@H:10]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:11][CH3:12]

Participants

4

Reactant 1

HCID 89546799HCID 89546799, compound

Product 1

HCID 89546797HCID 89546797, compoundYield 105.5%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

An MeOH (20 ml) solution containing tert-butyl ((3S,4R)-4-(benzyl (hydroxy)amino)pentan-3-yl)carbamate (39 mg) was subjected to a hydrogenation reaction (45° C.; 100 bar; flow rate: 1 ml/min; 20% Pd(OH)2/C) using H-Cube™. Then, the solvent was distilled away under reduced pressure. Colorless oily matter of tert-butyl ((3S,4R)-4-aminopentan-3-yl)carbamate (27 mg) was thus obtained.

Workup

  1. distillationThen, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-f68e31b60fa14547840b67cce9e647e7
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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