Potassium Carbonate → HCID 136341368, compound

HRID 2171332Notes

Reaction equation

HRID 2171332 reaction equation
CS(O[CH2:6][C:7]([NH:10][C:11]1[CH:16]=[C:15]([Cl:17])[N:14]=[C:13](Cl)[N:12]=1)([CH3:9])[CH3:8])(=O)=O.C(=O)([O-])[O-:20].[K+].[K+]>O1CCOCC1.O>[Cl:17][C:15]1[CH:16]=[C:11]2[NH:10][C:7]([CH3:9])([CH3:8])[CH2:6][N:12]2[C:13](=[O:20])[N:14]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86728316HCID 86728316, compound

Product 1

HCID 136341368HCID 136341368, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 2-((2,6-dichloropyrimidin-4-yl)amino)-2-methylpropyl methanesulfonate (3.00 g, 9.55 mmol) in 1,4-dioxane (15 mL) and water (15 mL) was added potassium carbonate (4.62 g, 33.4 mmol). The reaction mixture was stirred at 80° C. for 2 h, filtered, extracted with ethyl acetate (5 mL×2), dried over anhydrous Na2SO4, filtered and concentrated to give the crude product, which was used into next step without further purification.

Workup

  1. filtrationfiltered
  2. extractionextracted with ethyl acetate (5 mL×2)
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2aadc729d3704fceb7a7abe51a0302d1
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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