Ethyl trifluoroacetate → 2-(Trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol

HRID 2171352Notes

Reaction equation

HRID 2171352 reaction equation
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][NH2:5].[F:7][C:8]([F:15])([F:14])[C:9](OCC)=O>CC1C=CC(C)=CC=1>[F:7][C:8]([F:15])([F:14])[C:9]1[NH:1][CH2:2][CH:3]([OH:6])[CH2:4][N:5]=1

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 611571,3-Diamino-2-propanol

Product 1

HCID 200804282-(Trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol

Reagents, catalysts & solvents 1

HCID 7809P-XyleneSolvent

Procedure

A solution of 1,3-diaminopropan-2-ol (10.0 g, 111 mmol) and ethyl 2,2,2-trifluoroacetate (15.8 g, 111 mmol) in p-xylene (150 mL) was stirred at 160° C. for 4 h, then concentrated to remove solvent under reduced pressure to afford the crude product as an oil, which was used into next step without purification.

Workup

  1. concentrationconcentrated
  2. customto remove solvent under reduced pressure

Sources & evidence

ORD record
ord-a54823c242c74885bc4c655aae057fb6
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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