Ethyl trifluoroacetate → 2-(Trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol

Participants

Reaction Steps

A solution of 1,3-diaminopropan-2-ol (10.0 g, 111 mmol) and ethyl 2,2,2-trifluoroacetate (15.8 g, 111 mmol) in p-xylene (150 mL) was stirred at 160° C. for 4 h, then concentrated to remove solvent under reduced pressure to afford the crude product as an oil, which was used into next step without purification.

Provenance & Evidence