反应详情

温度

40 °C

To a solution of 3-chloro-5-(trifluoromethyl)pyridine (10.0 g, 55.1 mmol) in N,N-dimethylformamide (DMF) (150 mL) was added dropwise phenylmethanol (5.96 g, 55.1 mmol) under nitrogen at rt. The reaction mixture was stirred at 40° C. for 2 h, diluted with water (300 mL) and extracted with ethyl acetate (300 mL×3). Combined organic parts were washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product (100 g) was used into next step without further purification.

1. extractionextracted with ethyl acetate (300 mL×3)
2. washCombined organic parts were washed with brine
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated
5. customThe crude product (100 g) was used into next step without further purification