Isopropyl iodide → HCID 86728333, compound

HRID 2171360Notes

Reaction equation

HRID 2171360 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[NH:11][C:10]([CH3:13])([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.I[CH:15]([CH3:17])[CH3:16].C([O-])([O-])=O.[Cs+].[Cs+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]2[N:11]([CH:15]([CH3:17])[CH3:16])[C:10]([CH3:13])([CH3:12])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 10796Cesium carbonateHCID 136341368HCID 136341368, compound

Product 1

HCID 86728333HCID 86728333, compoundYield 8.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 7-chloro-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (400 mg, 2.00 mmol) and 2-iodopropane (375 mg, 2.20 mmol) in acetonitrile (7 mL) was added Cs2CO3 (1.31 g, 4.01 mmol). The reaction mixture was stirred at 90° C. for 2 h, filtered and concentrated. Purification via MDAP afforded the title product (40 mg) as a white solid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customPurification via MDAP

Sources & evidence

ORD record
ord-bcd2e0a6e1a64f62bfef274d10ffbb85
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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