4-(2-Fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile → 4-(4-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-fluorophenoxy)-2-(trifluoromethyl)benzonitrile

HRID 2171366Notes

Reaction equation

HRID 2171366 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH:10]([CH3:13])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[F:14][C:15]1[CH:33]=[C:32]([CH2:34][OH:35])[CH:31]=[CH:30][C:16]=1[O:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[C:20]([C:26]([F:29])([F:28])[F:27])[CH:19]=1>>[CH3:12][N:11]1[C:4]2[N:5]([C:6](=[O:8])[N:7]=[C:2]([O:35][CH2:34][C:32]3[CH:31]=[CH:30][C:16]([O:17][C:18]4[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[C:20]([C:26]([F:27])([F:28])[F:29])[CH:19]=4)=[C:15]([F:14])[CH:33]=3)[CH:3]=2)[CH2:9][CH:10]1[CH3:13]

Participants

3

Reactant 2

HCID 712397254-(2-Fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrileHCID 867283147-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 867283384-(4-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-2-fluorophenoxy)-2-(trifluoromethyl)benzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one and 4-(2-fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile.

Sources & evidence

ORD record
ord-bf6c0295c9ff4f60ac0fca99ada936fe
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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