Sodium hydride → (S)-7-((3,4-difluorobenzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

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Reaction Steps

To a solution of (3,4-difluorophenyl)methanol (45.4 mg, 0.315 mmol) in tetrahydrofuran (THF) (3 mL) was added dropwise sodium hydride (37.8 mg, 0.945 mmol) at 0° C. After 30 min, (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (90 mg, 0.32 mmol) was added. The reaction mixture was stirred at room temperature for 16 h, then concentrated. Purification via pre-TLC (ethyl acetate) afforded the title product.

Provenance & Evidence