2,4,5-Trifluorobenzyl Alcohol → (S)-1,2-dimethyl-7-((2,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171381Notes

Reaction equation

HRID 2171381 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[C@@H:10]([CH3:13])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[F:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[CH2:23][OH:24]>>[CH3:12][N:11]1[C:4]2[N:5]([C:6](=[O:8])[N:7]=[C:2]([O:24][CH2:23][C:16]3[CH:17]=[C:18]([F:22])[C:19]([F:21])=[CH:20][C:15]=3[F:14])[CH:3]=2)[CH2:9][C@@H:10]1[CH3:13]

Participants

3

Reactant 2

HCID 27770352,4,5-Trifluorobenzyl AlcoholHCID 86728322(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728357(S)-1,2-dimethyl-7-((2,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from (S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one and (2,4,5-trifluorophenyl)methanol.

Sources & evidence

ORD record
ord-0b28b233fe7647bcad6bebaae64e0fe1
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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