(3-Fluoro-4-(3-fluorophenoxy)phenyl)methanol → (S)-7-((3-fluoro-4-(3-fluorophenoxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171387Notes

Reaction equation

HRID 2171387 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:16][OH:17])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1.Cl[C:19]1[CH:20]=[C:21]2[N:28](C(OC(C)(C)C)=O)[C@@H:27]([CH3:36])[CH2:26][N:22]2[C:23](=[O:25])[N:24]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[CH2:16][O:17][C:19]1[CH:20]=[C:21]2[NH:28][C@@H:27]([CH3:36])[CH2:26][N:22]2[C:23](=[O:25])[N:24]=1

Participants

3

Reactant 2

HCID 28946122(3-Fluoro-4-(3-fluorophenoxy)phenyl)methanolHCID 86728347(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 86728362(S)-7-((3-fluoro-4-(3-fluorophenoxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3-fluoro-4-(3-fluorophenoxy)phenyl)methanol and (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-9d877eae13044dd897f52b1ad0254ccb
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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