2-Fluoro-5-(hydroxymethyl)benzonitrile → 2-Fluoro-5-(((1,2,2-trimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrile

HRID 2171400Notes

Reaction equation

HRID 2171400 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][C:3]=1[C:4]#[N:5].Cl[C:13]1[CH:14]=[C:15]2[N:22]([CH3:23])[C:21]([CH3:25])([CH3:24])[CH2:20][N:16]2[C:17](=[O:19])[N:18]=1>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:13]2[CH:14]=[C:15]3[N:22]([CH3:23])[C:21]([CH3:25])([CH3:24])[CH2:20][N:16]3[C:17](=[O:19])[N:18]=2)=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 27739342-Fluoro-5-(hydroxymethyl)benzonitrileHCID 867283457-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 867283802-Fluoro-5-(((1,2,2-trimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 2-fluoro-5-(hydroxymethyl)benzonitrile and 7-chloro-1,2,2-trimethyl-2,3-dihydroi-midazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-a6d6b7d922b043c9bcabdfaa177ebecc
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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