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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2171400Generated: November 1, 2026

2-Fluoro-5-(hydroxymethyl)benzonitrile → 2-Fluoro-5-(((1,2,2-trimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrile

https://huagongshe.com/reaction/2171400

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-5-(hydroxymethyl)benzonitrileHCID 2773934—
Reactant7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-oneHCID 86728345—
Product2-Fluoro-5-(((1,2,2-trimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrileHCID 86728380—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E9 starting from 2-fluoro-5-(hydroxymethyl)benzonitrile and 7-chloro-1,2,2-trimethyl-2,3-dihydroi-midazo[1,2-c]pyrimidin-5(1H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09051325B2
Source datasetuspto-grants-2015_06
ORD IDord-a6d6b7d922b043c9bcabdfaa177ebecc
Source noteuspto-grants-2015_06