(4-((2-Chloropyridin-4-yl)oxy)-3-fluorophenyl)methanol → 7-((4-((2-chloropyridin-4-yl)oxy)-3-fluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171432Notes

Reaction equation

HRID 2171432 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:10]=2[F:17])[CH:5]=[CH:4][N:3]=1.C(OC([N:25]1[C:33]2[N:28]([C:29](=[O:35])[N:30]=[C:31](Cl)[CH:32]=2)[CH2:27][C:26]1([CH3:37])[CH3:36])=O)(C)(C)C>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:31]3[CH:32]=[C:33]4[NH:25][C:26]([CH3:37])([CH3:36])[CH2:27][N:28]4[C:29](=[O:35])[N:30]=3)=[CH:11][C:10]=2[F:17])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 86724216(4-((2-Chloropyridin-4-yl)oxy)-3-fluorophenyl)methanolHCID 86728374tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 867284157-((4-((2-chloropyridin-4-yl)oxy)-3-fluorobenzyl)oxy)-2,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (4-((2-chloropyridin-4-yl)oxy)-3-fluorophenyl)methanol and tert-butyl-7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-110cbecfa3544371ac575cd34df73444
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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