3-Fluoro-5-(hydroxymethyl)benzonitrile → 3-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-5-fluorobenzonitrile

HRID 2171434Notes

Reaction equation

HRID 2171434 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH2:10][OH:11])[CH:9]=1)[C:5]#[N:6].Cl[C:13]1[CH:14]=[C:15]2[N:22]([CH3:23])[CH:21]([CH3:24])[CH2:20][N:16]2[C:17](=[O:19])[N:18]=1>>[CH3:23][N:22]1[C:15]2[N:16]([C:17](=[O:19])[N:18]=[C:13]([O:11][CH2:10][C:8]3[CH:7]=[C:4]([CH:3]=[C:2]([F:1])[CH:9]=3)[C:5]#[N:6])[CH:14]=2)[CH2:20][CH:21]1[CH3:24]

Participants

3

Reactant 2

HCID 686622523-Fluoro-5-(hydroxymethyl)benzonitrileHCID 867283147-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 867284173-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-5-fluorobenzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 3-fluoro-5-(hydroxymethyl)benzonitrile and 7-chloro-1,2-dimethyl-2,3-dihydroi-midazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-db7cbc219c03442ca12572a708c1150f
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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