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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2171434Generated: November 1, 2026

3-Fluoro-5-(hydroxymethyl)benzonitrile → 3-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-5-fluorobenzonitrile

https://huagongshe.com/reaction/2171434

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-5-(hydroxymethyl)benzonitrileHCID 68662252—
Reactant7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-oneHCID 86728314—
Product3-(((1,2-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)-5-fluorobenzonitrileHCID 86728417—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E9 starting from 3-fluoro-5-(hydroxymethyl)benzonitrile and 7-chloro-1,2-dimethyl-2,3-dihydroi-midazo[1,2-c]pyrimidin-5(1H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09051325B2
Source datasetuspto-grants-2015_06
ORD IDord-db7cbc219c03442ca12572a708c1150f
Source noteuspto-grants-2015_06