Cesium carbonate → HCID 86728419, compound

HRID 2171436Notes

Reaction equation

HRID 2171436 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[C:10]([CH3:14])([CH3:13])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[Cl:15][C:16]1[S:20][C:19]([CH2:21][CH2:22][OH:23])=[CH:18][CH:17]=1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C)C=O>[Cl:15][C:16]1[S:20][C:19]([CH2:21][CH2:22][O:23][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[C:10]([CH3:14])([CH3:13])[CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 63967770553653-39-7HCID 867283457-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728419HCID 86728419, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

To a solution of 7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (90.0 mg, 0.421 mmol) and 2-(5-chlorothiophen-2-yl)ethanol (68.5 mg, 0.421 mmol) in N,N-dimethylformamide (DMF) (3 mL) was added Cs2CO3 (274 mg, 0.842 mmol). The reaction mixture was stirred at 130° C. for 5 h, quenched with water. Purification via MDAP afforded the title product as a white solid.

Workup

  1. customquenched with water
  2. customPurification via MDAP

Sources & evidence

ORD record
ord-549e7b28c3c84208bb85059dd34f7cc4
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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