2,4,5-Trifluorobenzyl Alcohol → 1,2,2-trimethyl-7-((2,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171456Notes

Reaction equation

HRID 2171456 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[C:10]([CH3:14])([CH3:13])[CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[F:15][C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[CH2:24][OH:25]>>[CH3:12][N:11]1[C:4]2[N:5]([C:6](=[O:8])[N:7]=[C:2]([O:25][CH2:24][C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[F:15])[CH:3]=2)[CH2:9][C:10]1([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 27770352,4,5-Trifluorobenzyl AlcoholHCID 867283457-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 867284411,2,2-trimethyl-7-((2,4,5-trifluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one and (2,4,5-trifluorophenyl)methanol.

Sources & evidence

ORD record
ord-01eda625d2974088ab3f444a3181ae0f
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

Loading…