Hydrochloric Acid → HCID 178517482, compound

HRID 2171475Notes

Reaction equation

HRID 2171475 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](SCC)[N:12]2[CH:18]=[CH:19][N:20]=[C:11]2[CH:10]=1.[OH-:21].[K+].Cl.[Cl-].[NH4+]>CO.O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([OH:21])[N:12]2[CH:18]=[CH:19][N:20]=[C:11]2[CH:10]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 25517Ammonium ChlorideHCID 593131257-(2,4-Dichlorophenyl)-5-(ethylthio)imidazo[1,2-c]pyrimidine

Product 1

HCID 178517482HCID 178517482, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

16.6 g (51.19 mmol) of 7-(2,4-dichlorophenyl)-5-(ethylthio)imidazo[1,2-c]pyrimidine are dissolved in 330 ml of methanol, and 77 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is stirred at the reflux temperature for 2 h. After cooling, 300 ml of water are added and then, while cooling in ice, 140 ml of 0.1 molar hydrochloric acid. The mixture is then neutralized with saturated aqueous ammonium chloride solution and stirred for 10 min, and the solid is filtered off with suction. It is thoroughly washed with water and dried under high vacuum. 13.6 g (92% of theory) of the product are obtained as a solid.

Workup

  1. temperatureAfter cooling
  2. temperaturewhile cooling in ice
  3. stirringstirred for 10 min
  4. filtrationthe solid is filtered off with suction
  5. washIt is thoroughly washed with water
  6. customdried under high vacuum
  7. custom13.6 g (92% of theory) of the product are obtained as a solid

Sources & evidence

ORD record
ord-b354bc7ce94f44108ea38ae78e747b3a
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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