Trifluoroacetic acid → N-[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]ethane-1,2-diamine trifluoroacetate

HRID 2171478Notes

Reaction equation

HRID 2171478 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:15][CH2:16][CH2:17][NH:18]C(=O)OC(C)(C)C)[N:12]2[CH:26]=[CH:27][N:28]=[C:11]2[CH:10]=1.[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>ClCCl>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([NH:15][CH2:16][CH2:17][NH2:18])[N:12]2[CH:26]=[CH:27][N:28]=[C:11]2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59312979HCID 59312979, compound

Product 1

HCID 68710578N-[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]ethane-1,2-diamine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.42 g (10.47 mmol) of tert-butyl (2-{[7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethyl)carbamate are dissolved in 160 ml of dichloromethane, and 16 ml (209 mmol) of trifluoroacetic acid are added. The mixture is stirred at RT for 2 h and then removed from all volatile constituents in vacuo. 4.56 g (99% of theory) of product are obtained and are employed without further purification.

Workup

  1. customremoved from all volatile constituents in vacuo
  2. custom4.56 g (99% of theory) of product are obtained
  3. customare employed without further purification

Sources & evidence

ORD record
ord-484770969c63405c962c4fe445a30495
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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