反应详情

温度

120 °C

800 mg (4.13 mmol) of 5,7-dichloroimidazo[1,2-c]pyrimidine (Example 11A) are suspended in 20 ml of DMSO, and 1.62 g (4.54 mmol) of N6-(2-aminoethyl)-3-nitropyridine-2,6-diamine trifluoroacetate (Example 15A) and 1.6 g (12.38 mmol) of DIPEA are added. The mixture is heated at 120° C. for 16 h. After this time, water is added, and the precipitate which has separated out is filtered off with suction. It is washed with a little 2-propanol/water and the resulting solid is dried under high vacuum. 1.34 g (92% of theory) of the product are obtained as a solid.

1. customthe precipitate which has separated out
2. filtrationis filtered off with suction
3. washIt is washed with a little 2-propanol/water
4. customthe resulting solid is dried under high vacuum
5. custom1.34 g (92% of theory) of the product are obtained as a solid