Trifluoroacetic acid → HCID 68713943, compound

HRID 2171498Notes

Reaction equation

HRID 2171498 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([S:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)=[N:7][CH:8]=1)#[N:2].[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23]>ClCCl>[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].[NH2:12][CH2:11][CH2:10][S:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][N:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59313027tert-Butyl {2-[(5-cyanopyridin-2-yl)thio]ethyl}carbamate

Product 1

HCID 68713943HCID 68713943, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-[(2-Aminoethyl)thio]nicotinonitrile trifluoroacetate (Example 45A) is prepared in analogy to Example 40A from tert-butyl {2-[(5-cyanopyridin-2-yl)thio]ethyl}carbamate (Example 42A) (580 mg, 2.1 mmol) and trifluoroacetic acid (3.2 ml, 42 mmol) in dichloromethane (20 ml). 500 mg of the product are obtained.

Sources & evidence

ORD record
ord-90b1d8a414b147a48ac102f56c1340dd
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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