Phosphorus oxychloride → HCID 59312915, compound

HRID 2171526Notes

Reaction equation

HRID 2171526 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](O)[N:5]2[N:9]=[C:10]([CH2:12][CH3:13])[N:11]=[C:4]2[CH:3]=1.P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:6]1[N:5]2[N:9]=[C:10]([CH2:12][CH3:13])[N:11]=[C:4]2[CH:3]=[C:2]([Cl:1])[N:7]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178437473HCID 178437473, compound

Product 1

HCID 59312915HCID 59312915, compound

Procedure

In analogy to Example 11A, 285 mg (80% of theory) of the product are obtained from 312 mg (1.57 mmol) of 7-chloro-2-ethyl[1,2,4]triazolo[1,5-c]pyrimidin-5-ol (Example 102A) by reaction with phosphoryl chloride.

Sources & evidence

ORD record
ord-91e4366e1dbd4c52b0f2ff7eb33c04ce
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

Loading…