反应详情

温度

120 °C

2.07 g (7.4 mmol) of 7-[2,4-dichlorophenyl][1,2,4]triazolo[1,5-c]pyrimidin-5-ol (Example 137A) are introduced into phosphoryl chloride (20 ml), 5.0 g (22 mmol) of benzyltriethylammonium chloride are added, and the reaction mixture is stirred at 120° C. for 16 h. The reaction mixture is concentrated and cautiously poured onto ice, while stirring vigorously, and the mixture is stirred for 10 min. The solid is filtered off with suction. 1100 mg (50% of theory) of the product are obtained.

1. additionare added
2. concentrationThe reaction mixture is concentrated
3. additioncautiously poured onto ice
4. stirringwhile stirring vigorously
5. stirringthe mixture is stirred for 10 min
6. filtrationThe solid is filtered off with suction
7. custom1100 mg (50% of theory) of the product are obtained