反应详情

To a solution of (2S,3S)-methyl 3-hydroxypyrrolidine-2-carboxylate (16 g, 0.110 moles) in water (60 mL) was added NaNO2 (16 g, 0.220 moles) in water (30 mL) followed by the addition of glacial acetic acid (9.43 mL, 0.165 moles) at 0° C. and the reaction mixture was stirred for 4 h. Once the starting material had disappeared (monitored by TLC), the reaction mixture was diluted with ethyl acetate. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated to get the title compound which was used in the next step without purification.

1. washThe organic layer was washed with water, brine
2. dry with materialdried over Na2SO4
3. concentrationconcentrated