HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Furo[3,2-c]pyridin-2-ylmethyltriphenylphosphonium bromide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Furo[3,2-c]pyridine,2-(bromomethyl)-,hydrochloride | HCID 68939591 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | Furo[3,2-c]pyridin-2-ylmethyltriphenylphosphonium bromide hydrochloride | HCID 86629541 | — |
Reaction Steps
A solution of 2-bromomethylfuro[3,2-c]pyridine hydrochloride (Preparation 5, 2.12 g, 8.5 mmol) and PPh3 (2.24 g, 8.5 mmol) in anhydrous THF-EtOH (1:1, 80 mL) was heated under reflux for 3 d. The solvents were removed under reduced pressure, then the residual solid was triturated with hot THF to furnish the title compound: RT=2.32 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193359B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-34f05c75e491479cad1c39335ca59071 |
| Source note | uspto-grants-2012_06 |