反应详情

A solution of 2-bromomethylfuro[3,2-c]pyridine hydrochloride (Preparation 5, 2.12 g, 8.5 mmol) and PPh3 (2.24 g, 8.5 mmol) in anhydrous THF-EtOH (1:1, 80 mL) was heated under reflux for 3 d. The solvents were removed under reduced pressure, then the residual solid was triturated with hot THF to furnish the title compound: RT=2.32 min.

1. temperatureunder reflux for 3 d
2. customThe solvents were removed under reduced pressure
3. customthe residual solid was triturated with hot THF