5,5-DIMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OL → HCID 51029586, compound

HRID 2171743Notes

Reaction equation

HRID 2171743 reaction equation
[F:1][C:2]([C:6]1[N:11]2[CH2:12][C@@H:13]([CH2:15][O:16]S(C3C=CC(C)=CC=3)(=O)=O)[O:14][C:10]2=[N:9][C:8](=[O:27])[CH:7]=1)([F:5])[CH2:3][CH3:4].[CH3:28][C:29]1([CH3:40])[CH2:38][CH2:37][CH2:36][C:35]2[CH:34]=[C:33](O)[CH:32]=[CH:31][C:30]1=2>>[F:5][C:2]([C:6]1[N:11]2[CH2:12][C@@H:13]([CH2:15][O:16][C:33]3[CH:32]=[CH:31][C:30]4[C:29]([CH3:40])([CH3:28])[CH2:38][CH2:37][CH2:36][C:35]=4[CH:34]=3)[O:14][C:10]2=[N:9][C:8](=[O:27])[CH:7]=1)([F:1])[CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 202877025,5-DIMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OLHCID 86668128HCID 86668128, compound

Product 1

HCID 51029586HCID 51029586, compoundYield 32%

Procedure

The title compound was prepared from toluene-4-sulfonic acid (S)-5-(1,1-difluoro-propyl)-7-oxo-2,3-dihydro-7H-oxazolo[3,2-a]pyrimidin-2-ylmethyl ester (0.188 mmol) and 5,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ol (0.281, mmol,) according to the procedure described in Example 9. This afforded 24.0 mg (32%) of title compound.

Sources & evidence

ORD record
ord-b3376fa4d41441dd896bd52fc2c5e698
Source dataset
uspto-grants-2015_06
Patent number
US09051331B2

Reaction notes

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