Chlorosuccinimide → HCID 118023588, compound
Reaction equation
[CH3:1][C:2]1[NH:3][C:4](=[O:11])[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1.C1C(=O)N([Cl:19])C(=O)C1>CC(O)=O>[Cl:19][C:9]1[S:8][C:6]2[N:7]=[C:2]([CH3:1])[NH:3][C:4](=[O:11])[C:5]=2[CH:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
To a mixture of 2-methylthieno[2,3-d]pyrimidin-4(3H)-one (5.0 g) and AcOH (50 mL) was added NCS (4.8 g), followed by heating and stirring at 40° C. for 2 days. The reaction mixture was concentrated under reduced pressure. To the residue was added water, followed by stirring, and the precipitate was collected by filtration and then dried to obtain 6-chloro-2-methylthieno[2,3-d]pyrimidin-4(3H)-one (5.5 g).
Workup
- temperatureby heating
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionTo the residue was added water
- stirringby stirring
- filtrationthe precipitate was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-042bc755ed534f8880476def39e63df9
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09051339B2
Reaction notes
Loading…