反应详情

温度

40 °C

To a mixture of 2-methylthieno[2,3-d]pyrimidin-4(3H)-one (5.0 g) and AcOH (50 mL) was added NCS (4.8 g), followed by heating and stirring at 40° C. for 2 days. The reaction mixture was concentrated under reduced pressure. To the residue was added water, followed by stirring, and the precipitate was collected by filtration and then dried to obtain 6-chloro-2-methylthieno[2,3-d]pyrimidin-4(3H)-one (5.5 g).

1. temperatureby heating
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added water
4. stirringby stirring
5. filtrationthe precipitate was collected by filtration
6. customdried