Hydrochloric Acid → 2-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidine hydrochloride

HRID 2171990Notes

Reaction equation

HRID 2171990 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][N:8]2C(OC(C)(C)C)=O)[N:3]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)[N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68338143Tert-butyl 2-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate

Product 1

HCID 509881752-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a cooled solution of tert-butyl 2-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate (55 mg, 0.21 mmol; which may be prepared as described in Step 2) in dichloromethane (1.7 mL) was added dropwise HCl 4N in dioxane (1.3 mL). The solution was warmed to room temperature and stirred for 2 h. The solvent was evaporated under reduced pressure to give the title compound (47 mg, quantitative) as a white powder.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-439d5e64086940a791e304170775d486
Source dataset
uspto-grants-2015_06
Patent number
US09051321B2

Reaction notes

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