反应详情

Ethyl[2-(4-isopropylbenzoyl)hydrazino]acetate (4.85 g, 19.4 mmol) is treated with phosphorus oxychloride (50 mL), heated to reflux for 3 h, and then poured onto ice. The precipitate is collected and washed thoroughly with water and dried in the air to furnish 5-(4-isopropylphenyl)-1,3,4-oxadiazol-2(3H)-one (2.30 g, 58%) MS (ES+): m/e 205.

1. temperatureheated
2. temperatureto reflux for 3 h
3. additionpoured onto ice
4. customThe precipitate is collected
5. washwashed thoroughly with water
6. customdried in the air