Trifluoroacetic acid → HCID 15980062, compound

HRID 217219Notes

Reaction equation

HRID 217219 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:14]N)[CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]=[C:7]2[Cl:13].[F:16][C:17]([F:22])([F:21])[C:18](O)=O>>[Cl:13][C:7]1[C:6]2[C:11](=[C:2]([F:1])[CH:3]=[C:4]3[N:14]([CH2:18][C:17]([F:22])([F:21])[F:16])[CH:11]([CH3:6])[CH:2]([CH3:3])[C:5]3=2)[NH:10][C:9](=[O:12])[CH:8]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68930698HCID 68930698, compound

Product 1

HCID 15980062HCID 15980062, compound

Procedure

This compound was prepared using the method described in Example 23 from 8-fluoro-6-hydrazino-4-chloroquinolin-2(1H)-one and trifluoroacetic acid. Spectral data for compound 151: 1H NMR (500 MHz, acetone-d6) δ 10.36 (s, 1H), 7.06 (d, J=11.5 Hz, 1H), 6.78 (s, 1H), 4.11 (qn, J=6.8 Hz, 1H), 4.08 (dq, J=16.4, 9.9 Hz, 1H), 3.93 (dq, J=16.4, 9.2 Hz, 1H), 3.86 (qn, J=6.6 Hz, 1H), 1.45 (d, J=6.6 Hz, 3H), 1.17 (d, J=6.8 Hz, 3H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-11e32b3c629a40629a923cc304b198f6
Source dataset
uspto-grants-2012_06
Patent number
US08193357B2

Reaction notes

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