反应详情

Trifluoroacetic acid (40 ml) was added to a dichloromethane solution (40 ml) of 4-[2-(4-trifluoromethoxyphenoxy)ethyl]piperidine-1-carboxylic acid tert-butyl ester (18.6 g), and the mixture was stirred at room temperature for 5 hours. The mixture was concentrated under reduced pressure, and ice water was added to the resulting residue. The result was treated with 6 N sodium hydroxide aqueous solution, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over magnesium sulfate. The solvent was concentrated to dryness under reduced pressure to afford the title compound as a white powder (14 g).

1. concentrationThe mixture was concentrated under reduced pressure, and ice water
2. additionwas added to the resulting residue
3. additionThe result was treated with 6 N sodium hydroxide aqueous solution
4. extractionfollowed by extraction with ethyl acetate
5. washThe organic layer was washed with a saturated sodium chloride aqueous solution
6. dry with materialdried over magnesium sulfate
7. concentrationThe solvent was concentrated to dryness under reduced pressure