反应详情

A solution of 6 g 7-amino-2,4-dichloro-6-fluoro-benzothiazole and 4.3 g 3,4,5,6-tetrahydrophthalic anhydride in 50 ml acetic acid was heated under reflux for 5 hours. After cooling, the reaction solution was poured into 200 ml ice-water and the resulting crystals were separated off. They were dried at 50° C. in vacuo and then purified by column chromatography. Yield: 6.6 g=70% of theory m.p.: 139°-141° C.

1. temperatureunder reflux for 5 hours
2. temperatureAfter cooling
3. customthe resulting crystals were separated off
4. customThey were dried at 50° C. in vacuo
5. custompurified by column chromatography