Magnesium Stearate → Acrylate

HRID 2172528Notes

Reaction equation

[OH:1][CH:2]1[O:21][C@H](CO)[C@@H]([O:8][C@@H:9]2[O:17][C@H](CO)[C@H](O)[C@H:12](O)[C@H:10]2O)[C@H:5](O)[C@H:3]1O.O=[Si]=O.[C:27]([O-])(=O)CCCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=O)CCCCCCCCCCCCCCCCC>>[C:2]([O-:21])(=[O:1])[CH:3]=[CH2:5].[C:9]([O-:17])(=[O:8])[C:10]([CH3:27])=[CH2:12]

Participants

Reactant 3

HCID 11177Magnesium Stearate

HCID 24261Silica

HCID 440995(+)-Lactose

Product 2

HCID 25188Acrylate

HCID 87595Methacrylate

Procedure

Following the same procedure as for Example 1, a powdery mixture consisting of 0.53% (w/w) thiametoxam, 58.97% (w/w) cellulose acetate (CA 398-10, Eastman), 40% (w/w) lactose, 0.4% (w/w) aerosil and 0.1% (w/w) magnesium stearate is compacted into tablet cores (nominal weight: 39±1 mg) using convex punches. A coating solution formed of a mixture of acrylate and methacrylate copolymers (commercially available as Eudragit RS 30 D and Eudragit RL 30 D, Röhm GmbH, Germany) is sprayed on the cores.

Sources & evidence

ORD record: ord-5218f0cf604b4900b0bcef36fedeb687
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09055722B2

Reaction notes

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