1,2-Dibromopropane → HCID 19029914, compound

HRID 2172658Notes

Reaction equation

HRID 2172658 reaction equation
[C:1]1(=[O:15])[C:10]2[C:5]3[C:6](=[CH:11][CH:12]=[CH:13][C:4]=3[C:3](=[O:14])[NH:2]1)[CH:7]=[CH:8][CH:9]=2.[Br:16][CH2:17][CH:18](Br)[CH3:19]>>[Br:16][CH2:17][CH2:18][CH2:19][N:2]1[C:3](=[O:14])[C:4]2[CH:13]=[CH:12][CH:11]=[C:6]3[C:5]=2[C:10](=[CH:9][CH:8]=[CH:7]3)[C:1]1=[O:15]

Participants

3

Reactant 2

HCID 65531,2-DibromopropaneHCID 66491Naphthalimide

Product 1

HCID 19029914HCID 19029914, compound

Procedure

This compound was prepared according to GP-1 using benzo[de]isoquinoline-1,3-dione (1) and 1,2 dibromopropane (2a) The crude product was purified by flash column chromatography using EtOAc-hexane to provide 3a. 1H NMR (500 MHz, CDCl3) δ 8.62 (d, J=7.0 Hz 2H), 8.23 (d, J=8.0 Hz, 2H), 7.77 (t, J=7.5 Hz, 2H), 4.34 (t, J=7.5, 2H), 3.51 (t, J=7.0 Hz, 2H), 2.37-2.32 (m, 2H). MS (ES+) m/z 340 (M+Na)+.

Workup

  1. customThis compound was prepared
  2. customwas purified by flash column chromatography

Sources & evidence

ORD record
ord-7cdb3fb7cbf2459ab5f2df1e79997580
Source dataset
uspto-grants-2015_06
Patent number
US09056835B2

Reaction notes

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