Methyl 3-[bis(tert-butoxycarbonyl)amino]-5-iodothiophene-2-carboxylate → HCID 59481839, compound

HRID 217266Notes

Reaction equation

HRID 217266 reaction equation
[C:1]([O:5][C:6]([N:8]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:9]1[CH:13]=[C:12](I)[S:11][C:10]=1[C:15]([O:17][CH3:18])=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].CC1(C)C(C)(C)OB([C:34]2[CH:39]=[CH:38][C:37]([C:40]3[O:48][C:47]4[C:42](=[N:43][CH:44]=[CH:45][CH:46]=4)[CH:41]=3)=[CH:36][CH:35]=2)O1>>[C:1]([O:5][C:6]([N:8]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:9]1[CH:13]=[C:12]([C:34]2[CH:35]=[CH:36][C:37]([C:40]3[O:48][C:47]4[C:42](=[N:43][CH:44]=[CH:45][CH:46]=4)[CH:41]=3)=[CH:38][CH:39]=2)[S:11][C:10]=1[C:15]([O:17][CH3:18])=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 45480424Methyl 3-[bis(tert-butoxycarbonyl)amino]-5-iodothiophene-2-carboxylateHCID 57703583HCID 57703583, compound

Product 1

HCID 59481839HCID 59481839, compound

Procedure

Intermediate VII.5 was prepared starting from methyl 3-(bis[ter-butoxycarbonyl]amino)-5-iodo-2-thiophenecarboxylate and 2-[4(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]furo[3,2-b]pyridine (according to the general procedure in WO 2008/017688) as described for Intermediate VII.1. Intermediate VII.5 was used for the next step without purification.

Workup

  1. customIntermediate VII.5 was prepared
  2. customIntermediate VII.5 was used for the next step without purification

Sources & evidence

ORD record
ord-77d926414c9245038e015b2f394a2412
Source dataset
uspto-grants-2012_06
Patent number
US08193372B2

Reaction notes

Loading…