反应详情

温度

-5 °C

LiAlH4 (0.2 g) was added to THF (10 vol) slowly at 0 to −10° C. To this mixture was added a solution of compound 11a (3 g) in THF (15 mL) slowly over 30 min at 0 to −10° C. The reaction mixture was stirred at 0 to −10° C. for 4-12 hrs. The reaction was monitored by TLC. When the reaction was complete, it was quenched and the product was isolated by routine work up. The filtrate was concentrated under reduced pressure, and compound 12 was isolated as an oily mass; yield 14 g, 70-75%.

1. customit was quenched
2. customthe product was isolated by routine work up
3. concentrationThe filtrate was concentrated under reduced pressure