反应详情

To a solution of 3-aminorhodanine (1.00 g) in ethanol (20 ml) were added 4-phenoxybenzaldehyde (1.47 g) and piperidine (57 mg), and the mixture was heated with reflux for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: chloroform) to give 3-amino-5-(4-phenoxybenzylidene)-2-thioxothiazolidin-4-one (1.52 g).

1. temperaturethe mixture was heated
2. temperaturewith reflux for 2 hr
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (eluent: chloroform)