Hydrogen chloride-ethyl acetate → HCID 86725359, compound

HRID 2172837Notes

Reaction equation

HRID 2172837 reaction equation
[O:1]=[C:2]1[C:6](=[CH:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][CH2:16][NH:17]C(OC(C)(C)C)=O)[CH:9]=2)[S:5][C:4](=[S:25])[N:3]1[NH:26][C:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[S:29](=[O:37])(=[O:36])[N:28]=1.C(OCC)(=O)C.[ClH:44]>>[ClH:44].[O:1]=[C:2]1[C:6](=[CH:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][CH2:16][NH2:17])[CH:9]=2)[S:5][C:4](=[S:25])[N:3]1[NH:26][C:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[S:29](=[O:37])(=[O:36])[N:28]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86725361HCID 86725361, compound

Product 1

HCID 86725359HCID 86725359, compound

Procedure

3-[(4-Oxo-5-(3-(2-t-butoxycarbonylaminoethyloxy)benzylidene)-2-thioxothiazolidin-3-yl)amino]-1,2-benzothiazole 1,1-dioxide (220 mg) obtained in Example 167 was dissolved in 4M hydrogen chloride-ethyl acetate solution (10 ml), and the solution was stirred at room temperature for 3 hr, and concentrated under reduced pressure to give 3-[(4-oxo-5-(3-(2-aminoethyloxy)benzylidene)-2-thioxothiazolidin-3-yl)amino]-1,2-benzothiazole 1,1-dioxide hydrochloride (167 mg).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a52851c9cd97478a97c4659f87513e78
Source dataset
uspto-grants-2015_06
Patent number
US09056862B2

Reaction notes

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