m-Chloroperbenzoic acid → HCID 131729758, compound

HRID 217288Notes

Reaction equation

HRID 217288 reaction equation
Cl[C:2]1C=CC=C(C(OO)=O)C=1.[Cl:12][CH:13]1[CH:25]=[C:17]2[CH2:18][O:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:15]([C:16]=32)[C:14]1([C:28]1[N:33]=[C:32]([S:34](=O)(=[O:37])NC)[N:31]=[C:30]([NH2:39])[N:29]=1)[C:26]#[N:27]>C(Cl)Cl>[Cl:12][CH:13]1[CH:25]=[C:17]2[CH2:18][O:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:15]([C:16]=32)[C:14]1([C:28]1[N:33]=[C:32]([S:34]([CH3:2])=[O:37])[N:31]=[C:30]([NH2:39])[N:29]=1)[C:26]#[N:27]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 131729759HCID 131729759, compound

Product 1

HCID 131729758HCID 131729758, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

m-Chloroperbenzoic acid (7.10 g, 31.9 mmol) was added to a solution of 4-(5-chloro-6-cyano-1H,3H benzo[de]isochromen-6-yl)-6-methylsulfamyl-[1,3,5]triazin-2-ylamine (10.0 g, 29.0 mmol) in methylene chloride (100 mL) at room temperature. After the reaction solution was stirred at room temperature for 15 hours, the precipitate was collected by filtration. The resulting precipitate was suspended in methylene chloride, and stirred at room temperature for 3 hours. The insoluble material was collected by filtration, washed with methylene chloride, and dried under reduced pressure. The title compound was obtained as light brown solid (8.34 g, 79%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. stirringstirred at room temperature for 3 hours
  3. filtrationThe insoluble material was collected by filtration
  4. washwashed with methylene chloride
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-60fa658fa8d2456994805c4053daaea4
Source dataset
uspto-grants-2012_06
Patent number
US08193351B2

Reaction notes

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