反应详情

Indazole-4-carboxylic acid (2.00 g, 12.3 mmol) is suspended in methanol (20 mL) and toluene (30 mL) at room temperature. A solution of 2M trimethylsilyl diazomethane (12 mL, 24 mmol) in toluene is added slowly and the mixture is stirred at room temperature until the solution turned yellow. The reaction is quenched with concentrated acetic acid (5 mL) and the solvent is removed in vacuo. The residue is purified by silica gel chromatography eluting with a gradient of 0-30% ethyl acetate in hexanes to afford 1H-indazole-4-carboxylic acid methyl ester.

1. customat room temperature
2. customThe reaction is quenched with concentrated acetic acid (5 mL)
3. customthe solvent is removed in vacuo
4. customThe residue is purified by silica gel chromatography
5. washeluting with a gradient of 0-30% ethyl acetate in hexanes