HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanesulfinate → [1-(5-Methanesulfonyl-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanesulfinate | HCID 2733271 | — |
| Reactant | Sodium 1-Methyl 3-Sulfinopropionate | HCID 23665669 | — |
| Reactant | [1-(5-Iodo-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester | HCID 67115732 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | [1-(5-Methanesulfonyl-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester | HCID 68377483 | — |
Reaction Steps
[1-(5-Methanesulfonyl-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester is prepared from [1-(5-iodo-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (0.500 g, 1.43 mmol) according to the copper (I) iodide-mediated coupling procedure described in Example 19; however, sodium methanesulfinate is used as coupling partner instead of sodium 3-methoxy-3-oxopropane-1-sulfinate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056858B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-500e57a77e914bf281e7f0756adb24a5 |
| Source note | uspto-grants-2015_06 |