Hydrochloric Acid → 1-(5-Methanesulfonyl-furan-2-yl)-cyclopropylamine hydrochloride salt

HRID 2172969Notes

Reaction equation

HRID 2172969 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[O:12][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)(C)(C)C.O1CCOCC1.[ClH:27]>>[ClH:27].[CH3:19][S:16]([C:13]1[O:12][C:11]([C:8]2([NH2:7])[CH2:10][CH2:9]2)=[CH:15][CH:14]=1)(=[O:18])=[O:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68377483[1-(5-Methanesulfonyl-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester

Product 1

HCID 671158911-(5-Methanesulfonyl-furan-2-yl)-cyclopropylamine hydrochloride salt

Procedure

[1-(5-Methanesulfonyl-furan-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (0.430 g, 1.42 mmol) is dissolved in a 4M solution of HCl in dioxane (5.0 mL, 20 mmol) at room temperature. After stirring for 16 hours, the mixture is evaporated under a stream of nitrogen. The resulting oily solid is suspended in ethyl acetate (5 mL), ethyl ether (25 mL) is added, and the mixture is filtered to afford crude title product as a solid, which is used without purification.

Workup

  1. customthe mixture is evaporated under a stream of nitrogen
  2. additionethyl ether (25 mL) is added
  3. filtrationthe mixture is filtered

Sources & evidence

ORD record
ord-df202a845b9b48c39330ba3c8e3a086c
Source dataset
uspto-grants-2015_06
Patent number
US09056858B2

Reaction notes

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