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HRID2173003

反应详情

EQUATION

反应方程式

HRID 2173003 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](NC(=O)CO)[C@H]1OCc1ccc(Cl)c(Cl)c1
HCID67705253

未命名化合物

PRODUCTS

生成物

1
结构：Cl.N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](NC(=O)CO)[C@H]1OCc1ccc(Cl)c(Cl)c1
HCID86695985

未命名化合物

收率 133.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Add 4N hydrogen chloride (3.0 mL, 12.0 mmol) in 1,4-dioxane to a mixture of (1S,2R,3R,4S,5R,6S)-2-(tert-butoxycarbonylamino)-3-[(3,4-dichlorophenyl)methoxy]-4-[(2-hydroxyacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (0.032 g, 0.06 mmol) in water (0.3 mL). Wash the solid with acetonitrile and diethylether on a fritted funnel Sequentially wash the solid with acetonitrile and diethylether and then further dry in a vacuum oven overnight at 50° C. to provide the title compound as a white solid (0.018 g, 0.04 mmol, 65%). MS (m/z): 433 (M+H).

WORKUP

后处理

  1. washWash the solid with acetonitrile and diethylether on a fritted funnel
  2. washSequentially wash the solid with acetonitrile and diethylether
  3. customfurther dry in a vacuum oven overnight at 50° C.