4-Nitrophenethyl bromide → 1-[2-(4-Nitrophenyl)ethyl]-1,4-diazepane hydrochloride

HRID 2173109Notes

Reaction equation

HRID 2173109 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:7][CH:6]=1)([O-:4])=[O:3].[N+]([C:22]1C=CC(CCBr)=CC=1)([O-])=O.N1(C(OC(C)(C)C)=O)CCCNCC1>>[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][N:13]2[CH2:22][CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)=[CH:9][CH:10]=1)([O-:4])=[O:3]

Participants

4

Reactant 3

HCID 792664-Nitrophenethyl bromideHCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 666440061-[2-(4-Nitrophenyl)ethyl]piperazine hydrochloride

Product 1

HCID 675173471-[2-(4-Nitrophenyl)ethyl]-1,4-diazepane hydrochloride

Procedure

1-[2-(4-nitrophenyl)ethyl]-1,4-diazepane hydrochloride was prepared in an analogous fashion to that described above for 1-[2-(4-nitrophenyl)ethyl]piperazine hydrochloride starting with 4-nitrophenethyl bromide and tert-butyl 1,4-diazepane-1-carboxylate. LC-MS: M+1=250.2.

Sources & evidence

ORD record
ord-779644540e784c64aadd03ccc3e94a4f
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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