4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → HCID 67517283, compound

HRID 2173125Notes

Reaction equation

HRID 2173125 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2[C:25]([I:26])=[CH:24][C:19]3[C:20](=[O:23])[O:21][CH2:22][C:18]=3[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27].CC1C2COC(=O)C=2C=CC=1CCN1CCNCC1>O1CCOCC1>[ClH:27].[I:26][C:25]1[C:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][C:18]2[CH2:22][O:21][C:20](=[O:23])[C:19]=2[CH:24]=1

Participants

4

Reactant 2

HCID 675172294-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochlorideHCID 69087506HCID 69087506, compound

Product 1

HCID 67517283HCID 67517283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6-Iodo-5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride was prepared from tert-butyl-4-[2-(6-iodo-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate using 4N HCl in dioxane in an analogous fashion to that described for the synthesis of 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride above. LC-MS (IE, m/z): 373 [M+1]+.

Sources & evidence

ORD record
ord-0a89794b77c344e391621b5206893474
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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