1374572-68-5 → HCID 86692997, compound

HRID 2173128Notes

Reaction equation

HRID 2173128 reaction equation
[ClH:1].C[C:3]1[C:11]2[CH2:10][O:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.BrC1C([C:32]([F:35])([F:34])[F:33])=CC2C(=O)OCC=2C=1>>[ClH:1].[N:15]1([CH2:14][CH2:13][C:4]2[C:5]([C:32]([F:35])([F:34])[F:33])=[CH:6][C:7]3[C:8](=[O:12])[O:9][CH2:10][C:11]=3[CH:3]=2)[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 675158751374572-68-5HCID 675172294-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride

Product 1

HCID 86692997HCID 86692997, compound

Procedure

5-[2-(piperazin-1-yl)ethyl]-6-(trifluoromethyl)-2-benzofuran-1(3H)-one hydrochloride was prepared in an analogous fashion to that described for the synthesis of 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride above starting from 5-bromo-6-(trifluoromethyl)-2-benzofuran-1(3H)-one. LC-MS (IE, m/z): 315 [M+1]+.

Sources & evidence

ORD record
ord-872e6ea70b45425490ce0d40eb2331d6
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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