4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → HCID 67515896, compound

HRID 2173132Notes

Reaction equation

HRID 2173132 reaction equation
Cl.CC1C2COC(=O)C=2C=CC=1CCN1CCNCC1.C(OC([N:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][C:36]2[CH:45]=[CH:44][C:39]3[C:40](=[O:43])[O:41][CH2:42][C:38]=3[C:37]=2[CH:46]2[CH2:48][CH2:47]2)[CH2:30][CH2:29]1)=O)(C)(C)C>>[CH:46]1([C:37]2[C:38]3[CH2:42][O:41][C:40](=[O:43])[C:39]=3[CH:44]=[CH:45][C:36]=2[CH2:35][CH2:34][N:31]2[CH2:30][CH2:29][NH:28][CH2:33][CH2:32]2)[CH2:48][CH2:47]1

Participants

3

Reactant 2

HCID 675172294-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochlorideHCID 86692999HCID 86692999, compound

Product 1

HCID 67515896HCID 67515896, compound

Procedure

4-Cyclopropyl-5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one was prepared in a similar fashion to that described for the synthesis of 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride above starting from tert-butyl-4-[2-(4-cyclopropyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate. LC-MS (IE, m/z): 275 [M+1]+.

Sources & evidence

ORD record
ord-10c65b4d92134237befa3617eda1b8ee
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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