反应详情

A 1:1 solution of dioxane:3N HCl was added to a flask containing of 99 mg (0.49 mmol) of 6-(1,3-dioxolan-2-ylmethyl)-3-methyl-3,4-dihydro-1H-isochromen-1-one; the reaction was then stirred at room temp overnight. The crude reaction mixture was then partitioned between water and DCM. The organic layer was washed with saturated sodium bicarbonate solution, followed by brine. The organic layer was then dried with magnesium sulfate, filtered and concentrated.

1. customThe crude reaction mixture
2. customwas then partitioned between water and DCM
3. washThe organic layer was washed with saturated sodium bicarbonate solution
4. dry with materialThe organic layer was then dried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated