Hydrochloric Acid → HCID 67513832, compound

HRID 2173238Notes

Reaction equation

HRID 2173238 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(OC(C)(C)C)=O.[C:14]([C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[CH2:21]C=[CH:19]2)#[N:15].Cl>>[N:8]1([CH:1]2[CH2:19][C:18]3[C:22](=[CH:23][CH:24]=[C:16]([C:14]#[N:15])[CH:17]=3)[CH2:21]2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131732967HCID 131732967, compound

Product 1

HCID 67513832HCID 67513832, compound

Procedure

To a flask containing 5-cyano-inden bocpiperazine (0.025 g, 0.076 mmol) and a stir bar was added 4M HCl (2 mL). The resulting mixture was then stirred for 2 h; LC indicated completion of the reaction. The solution was concentrated in vacuo, pumped under reduced pressure and gave the title product (LC/MS: [(M+1)]+=228.

Workup

  1. customcompletion of the reaction
  2. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-d294cf5d72e24db5991de65e068f6123
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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